SIA

b-pharmacy (PCI) II year / I sem

New Syllabus (R17)

B.Pharmacy PCI (Semester-III) SET Of 4 SUBJECTS ( A Textbook Of Pharmaceutical Microbiology, A Textbook Of Pharmaceutical Engineering, A Textbook Of Physical Pharmaceutics-I, A Textbook Of Pharmaceutical Organic Chemistry-II) Revised Edition

B.Pharmacy PCI (Semester-III) SET Of 4 SUBJECTS ( A Textbook Of Pharmaceutical Microbiology, A Textbook Of Pharmaceutical Engineering, A Textbook Of Physical Pharmaceutics-I, A Textbook Of Pharmaceutical Organic Chemistry-II) Revised Edition

SET OF 4 SUBJECTS

1. A Textbook Of Pharmaceutical Microbiology
2. A Textbook Of Pharmaceutical Engineering
3. A Textbook Of Physical Pharmaceutics-I
4. A Textbook Of Pharmaceutical Organic Chemistry-II

New Syllabus (R17)

B.Pharmacy (Semester-III) All-in-One (As Per the Revised 2016-17 Regulations) (PCI) Pharmacy Council of India, Low Price 2020-21 Edition

B.Pharmacy (Semester-III) All-in-One (As Per the Revised 2016-17 Regulations) (PCI) Pharmacy Council of India, Low Price 2020-21 Edition

SUBJECTS COVERED

1. Pharmaceutical Organic Chemistry-II
2. Physical Pharmaceutics-I
3. Pharmaceutical Microbiology
4. Pharmaceutical Engineering.

New Syllabus (R17)

A Textbook of Pharmaceutical Microbiology (As per the Revised 2016-17 Regulations of the Pharmacy Council of India)

A Textbook of Pharmaceutical Microbiology (As per the Revised 2016-17 Regulations of the Pharmacy Council of India)

SYLLABUS

Unit-I

Introduction, history of microbiology, its branches, scope and its importance.
Introduction to prokaryotes and eukaryotes, study of ultra-structure and morphological classification of bacteria, nutritional requirements, raw materials used for culture media and physical parameters for growth. Growth curve, isolation and preservation methods for pure cultures, cultivation of anaerobes, quantitative measurement of bacterial growth (total & viable count).
Study of different types of phase contrast microscopy, dark field microscopy and electron microscopy.

Unit-II

Identification of bacteria using staining techniques (simple, Gram’s and acid fast staining) and biochemical tests (IMVIC).
Study of principle, procedure, merits, demerits and applications of physical, chemical, gaseous,radiation and mechanical methods of sterilization.
Evaluation of the efficiency of sterilization methods.
Equipments employed in large scale sterilization, sterility indicators.

Unit-III

Study of morphology, classification, reproduction/replication and cultivation of fungi and viruses.
Classification and mode of action of disinfectants.
Factors influencing disinfection, antiseptics and their evaluation for bacteriostatic and bactericidal actions. Evaluation of bactericidal & bacteriostatic.
Sterility testing of products (solids, liquids, ophthalmic and other sterile products) according to IP, BP and USP.

Unit-IV

Designing of aseptic area, laminar flow equipments, study of different sources of contamination in an aseptic area and methods of prevention, clean area classification.
Principles and methods of different microbiological assays. Methods for standardization of antibiotics, vitamins and amino acids.
Assessment of a new antibiotic.

Unit-V

Types of spoilage, factors affecting the microbial spoilage of pharmaceutical products, sources and types of microbial contaminants, assessment of microbial contamination and spoilage.
Preservation of pharmaceutical products using antimicrobial agents, evaluation of microbial stability of formulations.
Growth of animal cells in culture, general procedure for cell culture, primary, established and transformed cell cultures.
Application of cell cultures in pharmaceutical industry and research.

New Syllabus (R17)

A Textbook of Pharmaceutical Engineering (As per the Revised 2016-17 Regulations of the Pharmacy Council of India)

A Textbook of Pharmaceutical Engineering (As per the Revised 2016-17 Regulations of the Pharmacy Council of India)

SYLLABUS

Unit-I

Flow of Fluids:
Types of manometers, Reynold’s number and its significance, Bernoulli’s theorem and its applications. Energy losses, orifice meter, venturimeter, pitot tube and rotometer.
Size Reduction:
Objectives, mechanisms & laws governing size reduction, factors affecting size reduction, principles, construction, working, uses, merits and demerits of hammer mill, ball mill, fluid energy mill, edge runner mill & end runner mill.
Size Separation:
Objectives, applications & mechanisms of size separation. Official standards of powders, sieves. Size separation-principles, construction, working, uses, merits and demerits of sieve shaker, cyclone separator, air separator, bag filter & elutriation tank.

Unit-II

Heat Transfer:
Objectives, applications & heat transfer mechanisms. Fourier’s law, heat transfer by conduction, convection & radiation. Heat interchangers & heat exchangers.
Evaporation:
Objectives, applications and factors influencing evaporation, differences between evaporation and other heat process. Principles, construction, working, uses, merits and demerits of steam jacketed kettle, horizontal tube evaporator, climbing film evaporator, forced circulation evaporator, multiple effect evaporator & economy of multiple effect evaporator.
Distillation:
Basic principles and methodology of simple distillation, flash distillation, fractional distillation, distillation under reduced pressure, steam distillation & molecular distillation.

Unit-III

Drying:
Objectives, applications & mechanisms of drying process. Measurements & applications of equilibrium moisture content, rate of drying curve. Principles, construction, working, uses, merits and demerits of tray dryer, drum dryer, spray dryer, fluidized bed dryer, vacuum dryer, freeze dryer.
Mixing:
Objectives, applications & factors affecting mixing, Difference between solid and liquid mixing, mechanism of solid mixing, liquids mixing and semisolids mixing. Principles, construction, working, uses, merits and demerits of double cone blender, twin-shell blender, ribbon blender, sigma blade mixer, planetary mixers, propellers, turbines, paddles & silverson emulsifier.

Unit-IV

Filtration:
Objectives, applications, theories & factors influencing filtration, filter aids, filter medias. Principle, construction, working, uses, merits and demerits of plate & frame filter, filter leaf, rotary drum filter, meta filter & cartridge filter, membrane filters and seitz filter.
Centrifugation:
Objectives, principle & applications of centrifugation. Principles, construction, working, uses, merits and demerits of Perforated basket centrifuge, non-perforated basket centrifuge, semi continuous centrifuge & super centrifuge.

Unit-V

Materials of Pharmaceutical Plant Construction, Corrosion and its Prevention:
Factors affecting during materials selected for Pharmaceutical plant construction. Theories of corrosion, types of corrosion and their prevention. Ferrous and nonferrous metals, inorganic and organic non metals, basic of material handling systems.

New Syllabus (R17)

A Textbook of Physical Pharmaceutics-I (As per the Revised 2016-17 Regulations of the Pharmacy Council of India)

A Textbook of Physical Pharmaceutics-I (As per the Revised 2016-17 Regulations of the Pharmacy Council of India)

SYLLABUS

Unit-I

Solubility of Drugs: Solubility expressions, mechanisms of solute-solvent interactions, ideal solubility parameters, solvation and association, quantitative approach to the factors influencing solubility of drugs, diffusion principles in biological systems. Solubility gases in liquids, solubility of liquids in liquids, (binary solutions, ideal solutions) Raoult’s law, real Solutions. Partially miscible liquids, critical solution temperature and applications. Distribution law, its limitations and applications.

Unit-II

States of Matter and Properties of Matter: States of matter, changes in the states of matter, latent heats, vapour pressure, sublimation critical point, eutectic mixtures, gases, aerosols – inhalers, relative humidity, liquid complexes, liquid crystals, glassy states, solid-crystalline, amorphous and polymorphism. Physicochemical Properties of Drug Molecules: Refractive index, optical rotation, dielectric constant, dipole moment, dissociation constant, determinations and applications.

Unit-III

Surface and Interfacial Phenomenon: Liquid interface, surface and interfacial tensions, surface free energy, measurement of surface and interfacial tensions, spreading coefficient, adsorption at liquid interfaces, surface active agents, HLB scale, solubilisation, detergency and adsorption at solid interface.

Unit-IV

Complexation and Protein Binding: Introduction, classification of complexation, applications, methods of analysis, protein binding, complexation and drug action, crystalline structures of complexes and thermodynamic treatment of stability constants.

Unit-V

pH, Buffers and Isotonic Solutions: Sorensen’s pH scale, pH determination (electrometric and calourimetric), applications of buffers, buffer equation, buffer capacity, buffers in pharmaceutical and biological systems. Buffered isotonic solutions.

New Syllabus (R17)

A Textbook of Pharmaceutical Organic Chemistry-II (As per the Revised 2016-17 Regulations of the Pharmacy Council of India)

A Textbook of Pharmaceutical Organic Chemistry-II (As per the Revised 2016-17 Regulations of the Pharmacy Council of India)

SYLLABUS

Unit-I

Benzene and its Derivatives:
Analytical, synthetic and other evidences in the derivation of structure of benzene, orbital picture, resonance in benzene, aromatic characters, Huckel’s rule.
Reactions of benzene - nitration, sulphonation, halogenation-reactivity, Friedel Crafts alkylation- reactivity, limitations and Friedel Crafts acylation.
Substituents, effect of substituents on reactivity and orientation of monosubstituted benzene compounds towards electrophilic substitution reaction.
Structure and uses of DDT, saccharin, BHC and chloramine.

Unit-II

Phenols:
Acidity of phenols, effect of substituents on acidity, qualitative tests, structure and uses of phenol, cresols, resorcinol, naphthols.
Aromatic Amines:
Basicity of amines, effect of substituents on basicity and synthetic uses of aryl diazonium salts.
Aromatic Acids:
Acidity, effect of substituents on acidity and important reactions of benzoic acid.

Unit-III

Fats and Oils:
Fatty acids – reactions.
Hydrolysis, hydrogenation, saponification and rancidity of oils, drying of oils.
Analytical constants –Acid value, saponification value, ester value, iodine value, acetyl value, Reichert Meissle (RM) value – significance and principle involved in their determination.

Unit-IV

Polynuclear Hydrocarbons:
(a) Synthesis, reactions
(b) Structure and medicinal uses of naphthalene, phenanthrene, anthracene, diphenylmethane, triphenylmethane and their derivatives.

Unit-V

Cycloalkanes:
Stabilities – Baeyer’s strain theory, limitation of Baeyer’s strain theory, Coulson and Moffitt’s modification, Sachse Mohr’s theory (Theory of Strainless Rings), reactions of cyclopropane and cyclobutane only